Zn+2 In Serum

From Anvita Health Wiki

Contents 1 Indications 2 Reference-interval 3 Clinical-significance 4 Increases 5 Decreases 6 Methods 7 Specimen 8 Interferences 9 More General Terms 10 Additional Terms 11 References

Indications

• assessment of zinc deficiency
• assessment of zinc toxicity

Reference-interval

• 60-130 ug/ dL (9-20 umol/L)

Clinical-significance

• 75-88% of Zn+2 in whole blood is in erythrocytes
• levels in erythrocytes 15 times that of plasma
• no body stores of zinc

Increases

• zinc toxicity

• acidic beverages & foods in Zinc containers
• excessive Zinc supplementation

• high-dose zinc therapy may result in copper deficiency & acquired sideroblastic anemia

• hemodialysis against a diasylate high in Zn+2
• pharmaceuticals

• chlorthalidone, penicillamine

• osteosarcoma of bone
• arteriosclerosis, coronary artery disease
• anemia

Decreases

• zinc deficiency
• dwarfism
• acrodermatitis enteropathica
• acute tissue injury

• acute myocardial infarction

• chronic liver disease

• severe hepatocellular disease

• sickle cell disease
• some cancers

• colon cancer
• lung cancer
• metastatic cancer to liver
• leukemias
• lymphomas

• parenteral nutrition (Zn+2-deficient, several weeks)
• hypoalbuminemia*
• stress
• infection

• typhoid fever
• pulmonary tuberculosis

• pregnancy
• malnutrition or decreased Zn+2 absorption

• celiac disease

• pica (Zn+2-binding agents)
• burns
• thalassemia major
• pharmaceuticals

• estrogens, cisplatin, corticosteroids, interferon, phenytoin, thiazides
  

• * 50% of serum Zn+2 is bound to albumin

Methods

• measurement by atomic absorption spectroscopy

Specimen

• serum or plasma
• fasting morning specimen
• Collect in acid-washed polypropylene container, zinc-free vacuum tubes or metal-free glass. Avoid hemolysis.
• Separate from cells within 45 minutes

Interferences

• rubber stoppers on vacutainers & storage containers may be a significant source of contamination

More General Terms

• special chemistry test

Additional Terms

• zinc deficiency
• Zn+2

References

1. Bakerman's ABC's of Interpretive Laboratory Data Bakerman S, Bakerman P, Strausbach P Interpretive Laboratory Data In, Scottsdale 2002
2. Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995

zinc (Zn+2) in serum