Zinc Finger Protein 202
From Anvita Health Wiki
Contents |
Function
- transcriptional repressor
- binds to elements found predominantly in genes that participate in lipid metabolism
- among its targets are
- structural components of lipoprotein particles ( apolipoproteins apoA4, apoC3, & apoE)
- enzymes involved in lipid processing
- lipoprotein lipase
- lecithin-cholesteryl ester transferase
- transporters involved in lipid homeostasis ( ABCA1, ABCG1)
- several genes involved in processes related to energy metabolism & vascular disease
- interacts with SDP1
Structure
- contains 8 C2H2-type Zn+2 fingers
- contains 1 KRAB domain
- contains 1 SCAN box domain
Compartment
Alternative-splicing
- named isoforms=2; alpha
Expression
- highly expressed in testis
Pathology
- also expressed in breast carcinoma cell lines
More General Terms
Internet Database
Kegg: [1]
OMIM: 603430
Prosite: [2]
Prosite: [3]
Prosite: [4]
Prosite: [5]
UniProt: [6]
Entrez gene: 7753
References
