Yersinia Pestis

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Contents 1 Introduction 2 Pathology 3 Management 4 More General Terms 5 Additional Terms 6 References

Introduction

• Non- motile gram negative bacillus.

Pathology

• etiologic agent of plague
• rhoA serves as a target for the yopT cysteine peptidase from Yersinia pestis & Yersinia pseudotuberculosis
• rhoA is cleaved by yopT protease when the cell is infected by Yersinia; this removes the lipid attachment, & leads to its displacement from plasma membrane & to subsequent cytoskeleton cleavage

Management

• streptomycin or gentamicin
• alternative agents

• doxycycline
• fluoroquinolone

More General Terms

• Yersinia

Additional Terms

• plague

References

1. Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 798-99
2. Medical Knowledge Self Assessment Program (MKSAP) 15, American College of Physicians, Philadelphia 2009

Yersinia pestis