Yellow Nail Syndrome

From Anvita Health Wiki

Contents 1 Introduction 2 Genetics 3 Clinical-manifestations 4 More General Terms 5 Internet Database 6 References

Introduction

• Clinical triad of:
• opaque yellow & dystrophic nails
• lymphatic abnormalities

• aplasia
• ectasia
• lymphedema
• lymphangitis

• systemic illness

• pulmonary disease

• bronchiectasis (20%)
• pleural effusion (30-40%)

• cancer

• Hodgkin's lymphoma
• endometrial carcinoma
• melanoma
• lymphoma

Genetics

• autosomal disorder
• associated with defects in FOXC2 gene

Clinical-manifestations

• diffuse yellow to green discoloration of the fingernails & toenails
• nail thickening
• slowed growth
• excessive curvature from side to side
• edema of the fingertips, ankles & face may occur
• sinusitis may be present
• Raynaud's phenomenon may be present
• pleural effusion (30-40%)

• lymphocyte predominant
• may appear years after nail changes occur
• tend to be small to moderate in size
• tend to be bilateral
• exudative or transudative

• lymphedema

• lower extremities
• may affect breasts

More General Terms

• nail disease
• lung disease
• syndrome

Internet Database

OMIM: 153300

References

1. Color Atlas & Synopsis of Clinical Dermatology, Common & Serious Diseases, 3rd ed, Fitzpatrick et al, McGraw Hill, NY, 1997, pg 498
2. Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 179

yellow nail syndrome (lymphedema & yellow nails)