X Ray Radiation Resistance Associated Protein 1

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Alternative-splicing 5 Expression 6 Pathology 7 More General Terms 8 Internet Database 9 References

Function

• may be involved in the response of cells to X-ray radiation

Structure

• contains 6 LRR repeats ( leucine-rich repeats)

Compartment

• cytoplasm. nucleus

Alternative-splicing

• named isoforms=4 gene model based on mouse cDNA data

Expression

• expressed predominantly in testis
• expressed in prostate & ovary > other tissues including peripheral blood leukocytes, spleen, thymus, small intestine & colon

• induced by X-ray radiation immediately after exposure & is then down-regulated two-fold in an X-ray radiation-resistant cell clone. responds differently to X-ray radiation in clones of varying radiation responses

Pathology

• expressed in neuroblastoma, glioma, breast cancer, lung cancer, leukemia, renal cell carcinoma, ovarian cancer, prostate cancer, & colorectal cancer cell lines

More General Terms

• uncharacterized protein

Internet Database

UniProt: [1]

References

UniProt [2]

X-ray radiation resistance-associated protein 1 (XRRA1)