Vorinostat

From Anvita Health Wiki

Contents 1 Indications 2 Dosage 3 Mechanism-of-action 4 More General Terms 5 Internet Database 6 References

Indications

• advanced skin cancer

Dosage

• oral

Mechanism-of-action

• histone deacetylase inhibitor; inhibits HDAC2
• enhances memory in mice [2]

More General Terms

• antineoplastic agent (chemotherapeutic agent)
• enzyme inhibitor

Internet Database

PubChem: 5311

References

1. Prescriber's Letter 14(2): 2007 New drugs approved by the FDA in 2006 Detail-Document#: [1] (subscription needed) [2]
2. Guan J-S et al. HDAC2 negatively regulates memory formation and synaptic plasticity Nature 2009 May 7; 459:55. PMID: [3]
3. Gräff J et al. An epigenetic blockade of cognitive functions in the neurodegenerating brain. Nature 2012 Mar 8; 483:222 PMID: [4]

vorinostat (Zolinza, SAHA)