Voltage Gated K+ Channel Alpha Subunit

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Contents 1 More Specific Terms 2 Introduction 3 More General Terms 4 References

More Specific Terms

• K+ voltage-gated channel subfamily A member 10 (voltage-gated K+ channel subunit Kv1.8, KCNA10)
• K+ voltage-gated channel subfamily A member 1; voltage-gated K+ channel subunit Kv1.1; HUKI; HBK1 (KCNA1)
• K+ voltage-gated channel subfamily A member 2; voltage-gated K+ channel subunit Kv1.2; HBK5; NGK1; HUKIV (KCNA2, RBK2, RCK5, MK2)
• K+ voltage-gated channel subfamily A member 3; voltage-gated K+ channel subunit Kv1.3; HPCN3; HGK5; HuKIII; HLK3 (KCNA3, HGK5)
• K+ voltage-gated channel subfamily A member 4 (voltage-gated K+ channel subunit Kv1.4, HK1, HPCN2, HBK4, HUKII, KCNA4, KCNA4L)
• K+ voltage-gated channel subfamily A member 5 (voltage-gated K+ channel subunit Kv1.5, HK2, HPCN1, KCNA5)
• K+ voltage-gated channel subfamily A member 6; voltage-gated K+ channel subunit Kv1.6; HBK2 (KCNA6)

Introduction

• Struture
• four alpha subunits combine to form a functional voltage-gated K+ channel
• between transmembrane domains 5 & 6 is an exoplasmic loop containing the pore-forming region ( H5 region)

More General Terms

• transmembrane 6 protein
• oligomerizing protein
• K+ channel
• ion channel subunit
• phosphoprotein

References

1. Kubo Y, Baldwin TJ, Jan YN, Jan LY. Primary structure and functional expression of a mouse inward rectifier potassium channel. Nature. 1993 Mar 11;362(6416):127-33. PMID: [1]
2. Martens JR, Kwak YG, Tamkun MM. Modulation of Kv channel alpha/beta subunit interactions. Trends Cardiovasc Med. 1999 Nov;9(8):253-8. Review. PMID: [2]

voltage-gated K+ channel alpha subunit