Voltage Dependent Ca+2 Channel
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Contents |
More Specific Terms
- cation channel sperm-associated protein 2 (Catsper2, CATSPER2)
- L-type Ca+2 channel, long duration or slowly inactivating Ca+2 channel or dihydropyridine receptor (R-type Ca+2 channel)
- N-type Ca+2 channel or neuronal-type Ca+2 channel
- NMDA receptor
- P-type Ca+2 channel or Purkinje cell Ca+2 channel
- T-type Ca+2 channel or transient current Ca+2 channel
Function
- voltage-sensitive Ca+2 channels (VSCC) mediate the entry of Ca+2 into excitable cells
- roles in a variety of Ca+2-dependent processes, including
- muscle contraction
- hormone or neurotransmitter release
- gene expression
- cell motility
- cell division
- cell death
Structure
- multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2-delta (CACNA2D), beta (CACNB) subunits in a 1:1:1 ratio
- alpha-2-delta transcribed from a single gene; unclear if protein is cleave into separate alpha-2 & delta subunits
- L-type Ca+2 channels also contain a gamma subunit
- the channel activity is directed by the pore-forming & voltage-sensitive alpha-1 subunit
- in many cases, the alpha-1 subunit is sufficient to generate voltage-sensitive Ca+2 channel activity
- the auxiliary subunits beta & alpha-2/delta linked by a disulfide bridge regulate channel activity
More General Terms
References
UniProt [1]
