Vitamin K Epoxide Reductase Complex Subunit 1

From Anvita Health Wiki

Contents 1 Function 2 Compartment 3 Alternative-splicing 4 Expression 5 Pathology 6 More General Terms 7 Additional Terms 8 Internet Database 9 References

Function

• catalytic subunit of vitamin K epoxide reductase complex
• location of Cys within a proposed transmembrane is consistent both with the known hydrophobic environment of the thiol redox site of the enzyme & the lipophilicity of vitamin K & warfarin

Compartment

• endoplasmic reticulum membrane

Alternative-splicing

• named isoforms=2

Expression

• expressed in fetal & adult liver > fetal heart, kidney, & lung, adult heart & pancreas

Pathology

• defects in VKORC1 are associated with combined deficiency of all vitamin K-dependent clotting factors type 2
• defects in VKORC1 are associated with warfarin resistance

More General Terms

• enzyme catalytic subunit
• transmembrane 3 protein

Additional Terms

• warfarin sensitivity testing (CYP2C9 & VKORC1)

Internet Database

OMIM: 122700
OMIM: 607473
OMIM: 608547
UniProt: [1]

References

UniProt [2]

vitamin K epoxide reductase complex subunit 1 (vitamin K1 2,3-epoxide reductase subunit 1, VKORC1, VKOR, MSTP134, MSTP576, UNQ308/PRO351)