Vinorelbine

From Anvita Health Wiki

Contents 1 Indications 2 Dosage 3 Pharmacokinetics 4 Adverse-effects 5 Drug-interactions 6 Mechanism-of-action 7 More General Terms 8 Additional Terms 9 Internet Database 10 References

Indications

• lymphoma
• metastatic breast cancer
• non-small cell lung cancer, alone or in combination with cisplatin

Dosage

• 15-30 mg/m2 IV weekly
• dosage adjustment for bilirubin > 3.0 mg/dL: 7.5 mg/m2
• dilute prior to administration
• ensure IV access

• Injection: 10 mg/mL (1 mL, 5 mL).

Pharmacokinetics

• widely distributed
• metabolized by the liver
• eliminated in the urine & feces
• elimination 1/2life approximately 23 hours
  

• elimination via kidney
• 1/2life = 23 hours

Adverse-effects

• not common (1-10%)

• chest pain, decreased deep tendon reflexes, tumor pain, jaw pain, paresthesia, phlebitis at site of infusion, nausea/vomiting, constipation, abnormal liver function tests, dyspnea (acute & reversible), hypoxemia, interstitial pulmonary infiltrates, SIADH, fatigue, hemorrhagic cystitis

• uncommon (< 1%)

• alopecia, thrombocytopenia, myocardial infarction

• other

• myelosuppression

• leukopenia, neutropenia, anemia
• thrombocytopenia (uncommon)
• nadir 7-8 days
• recovery 15-17 days

• irritant/ extravasation
• peripheral neuropathy
• ileus
• urinary retention
• ototoxicity

Drug-interactions

• aminoglycosides given within 3-5 days can increase the risk of ototoxicity
• mitomycin-C in combination may result in acute pulmonary syndrome which may occur up to 2 weeks after last dose of mitomycin-C

Mechanism-of-action

• vinca alkaloid
• inhibits microtubule formation in the mitotic spindle arresting cell division

More General Terms

• antineoplastic agent (chemotherapeutic agent)
• vinca alkaloid

Additional Terms

• intravenous (IV) extravasation

Internet Database

PubChem: 60779
PubChem: 5311497
PubChem: 60780
PubChem: 5672

References

1. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
2. Kaiser Permanente Northern California Regional Drug Formulary, 1998

vinorelbine (Navelbine)