Vemurafenib

From Anvita Health Wiki

Contents 1 Indications 2 Adverse-effects 3 Laboratory 4 Mechanism-of-action 5 More General Terms 6 Internet Database 7 References

Indications

• metastatic melanoma ( BRAF V600E positive)

Adverse-effects

• rash
• photosensitivity
• joint pain
• hair loss
• fatigue
• cutaneous squamous cell carcinoma

Laboratory

• BRAF V600E mutation

Mechanism-of-action

• BRAF inhibitor

• designed to selectively target & inhibit a mutated form of BRAF

More General Terms

• monoclonal antibody
• antineoplastic agent (chemotherapeutic agent)

Internet Database

PubChem: 42611257

References

1. New Drug Applications [1]
2. FDA NEWS RELEASE: Aug. 17, 2011 FDA approves Zelboraf and companion diagnostic test for late-stage skin cancer

vemurafenib (Zelboraf, PLX4032)