Ustekinumab

From Anvita Health Wiki

Contents 1 Indications 2 Contraindications 3 Dosage 4 Adverse-effects 5 Mechanism-of-action 6 More General Terms 7 References

Indications

• adult plaque psoriasis (moderate to severe psoriasis) resistant to methotrexate, PUVA, cyclosporine or contraindication to these agents

Contraindications

• clinically significant active infection

Dosage

• 45 mg (injection)
• 90 mg if > 100 kg

Adverse-effects

• immmosuppression

• increased risk of

• fungal infection
• viral infection
• bacterial infection

• depression, headache, dizziness, fatigue
• diarrhea
• pruritus
• back pain
• injection site erythema
• may increase risk of malignancies

Mechanism-of-action

• monoclonal antibody directed against interleukin-12 & interleukin-23

More General Terms

• monoclonal antibody
• dermatologic agent

References

1. FDA News release [1]
2. Prescriber's Letter 16(11): 2009 Stelara (Ustekinumab) for Psoriasis Detail-Document#: [2] (subscription needed) [3]
3. National Guideline Clearinghouse Ustekinumab for the treatment of adults with moderate to severe psoriasis. National Institute for Health and Clinical Excellence (NICE) ngc-guideline: [4]

ustekinumab (Stelara)