Uromodulin
From Anvita Health Wiki
Contents |
Function
- most abundant protein in human urine
- function unknown
- may function to bind bacteria through its mannose-containing residues, preventing bacterial colonization of the uroepithelium
- may play a role in regulating the circulating activity of cytokines as it binds to IL-1, IL-2 & TNF with high affinity
Structure
- glycoprotein
- contains 3 EGF-like domains
- contains 1 ZP domain
Compartment
- cell membrane; lipid-anchor, GPI-anchor
- secreted after cleavage into the urine
Alternative-splicing
- named isoforms=3
Expression
- produced by cells of the ascending loop of Henle & the adjacent distal convoluted tubule of the kidney
- most abundant protein in human urine
Pathology
- uromodulin is the primary constituent of hyaline casts
- defects in UMOD are the cause of:
- defects in UMOD are a cause of glomerulocystic kidney disease with hyperuricemia & isosthenuria
More General Terms
Internet Database
UniProt: [1]
Entrez gene: 7369
Kegg: [2]
OMIM: 162000
OMIM: 191845
OMIM: 603860
OMIM: 609886
Prosite: [3]
Prosite: [4]
Prosite: [5]
Prosite: [6]
Prosite: [7]
Prosite: [8]
Prosite: [9]
References
