Ubiquitination

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Contents 1 Introduction 2 More General Terms 3 Additional Terms 4 References

Introduction

• Conjugation of a target protein with ubiquitin. Ubiquitin modifies an epsilon amino group of lysine in the target protein via its C-terminal carboxyl-group.

• Ubiquitin is covalently attached to target proteins by a multienzymatic system consisting of E1 ( ubiquitin-activating), E2 ( ubiquitin-conjugating), & E3 ( ubiquitin-ligating) enzymes.
• Poly-ubiquitination generally targets a protein for proteasome- mediated proteolysis, whereas mono-ubiquitination regulates other cellular processes, including:

• endocytosis [3]
• alteration of chromatin structure after conjugation of histones [4]

More General Terms

• protein conjugation

Additional Terms

• ubiquitin (RPS27A, UBA80, UBCEP1, UBA52, UBCEP2, UBB, UBC)

References

1. Gene Ontology Browser (Mouse) GO:0016925 [1]
2. url>http://www.biocarta.com/pathfiles/h_sumoPathway.asp</url>
3. Li Y, Wang H, Wang S, Quon D, Liu YW, Cordell B. Positive and negative regulation of APP amyloidogenesis by sumoylation. Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):259-64. Epub 2002 Dec 27. Erratum in: Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):9102. PMID: [2]
4. Lieberman AP. SUMO, a ubiquitin-like modifier implicated in neurodegeneration. Exp Neurol. 2004 Feb;185(2):204-7. Review. PMID: [3]

ubiquitination