Trimethadione

From Anvita Health Wiki

Contents 1 Introduction 2 Indications 3 Dosage 4 Pharmacokinetics 5 Adverse-effects 6 More General Terms 7 Internet Database 8 References

Introduction

• Tradename: Tridione.

Indications

• seizures: absence ( petit mal)

• atypical absence ( intractable seizures only)

Dosage

• 900-1200 mg PO QD.

Pharmacokinetics

• demethylated to dimethadione (active metabolite)
• 1/2 life of dimethadione (active metabolite) is 6-13 days
  

• 1/2life = 6-13 days dimethadione
• protein binding = <5 % small

Adverse-effects

• Neurologic: sedation, blurred vision
• Systemic: skin rash, bone marrow suppression, nephrosis, hepatitis
  
• drug adverse effects of anticonvulsants

More General Terms

• anticonvulsant
• oxazole; 1,3 oxazole

Internet Database

PubChem: 5576

References

Harrison's Principles of Internal Medicine, 13th ed. Companion Handbook. Isselbacher et al (eds), McGraw-Hill Inc. NY, 1995, pg 701.

trimethadione (Tridione)