Transient Receptor Potential Cation Channel Subfamily M Member 8

From Anvita Health Wiki

Contents 1 Function 2 Compartment 3 Alternative-splicing 4 Expression 5 Pathology 6 Pharmacology 7 More General Terms 8 Internet Database 9 References

Function

• receptor-activated non-selective cation channel
• detection of sensations such as coolness

• activated by cold temperature below 25 degrees Celsius

• activated by icilin, eucalyptol, menthol, cold, modulation of intracellular pH
• involved in menthol sensation
• sensation of coolness triggered by eucalyptol or menthol results from menthol & cool temperatures sensations detected by same protein
• permeable for Na+, K+, Cs+ & Ca+2
• temperature sensing is tightly linked to voltage-dependent gating
• activated upon depolarization

• changes in temperature result in graded shifts of voltage-dependent activation

• agonist menthol functions as gating modifier

• shifts activation curves towards physiological membrane potentials

Compartment

• membrane

Alternative-splicing

• named isoforms=3

Expression

• expressed in prostate & most prostate tumors

Pathology

• expressed in other tumors: (other than prostate tumors)

• colon cancer, lung cancer, breast cancer, skin cancer

Pharmacology

• may be suitable antigen for vaccination against prostate cancer

More General Terms

• transient receptor potential cation channel subfamily M (TRPM)
• Ca+2 channel
• Na+ channel
• transmembrane 6 protein

Internet Database

OMIM: 606678
UniProt: [1]

References

UniProt [2]

transient receptor potential cation channel subfamily M member 8 (TrpM8, transient receptor potential-p8, Trp-p8, long transient receptor potential channel 6, LTrpC6, TRPP8)