Transient Receptor Potential Cation Channel Subfamily M Member 6

From Anvita Health Wiki

Contents 1 Function 2 Expression 3 Pathology 4 More General Terms 5 Additional Terms 6 Internet Database 7 References

Function

• ion channel & serine/threonine protein kinase
• involved in magnesium homeostasis

• epithelial magnesium transport
• active magnesium absorption in the gut & kidney

• forms heterodimers with TRPM7

Expression

• expressed in kidney & colon

Pathology

• defects in TRPM6 are the cause of hypomagnesemia with secondary hypocalcemia

More General Terms

• transmembrane 6 protein
• ion channel
• serine/threonine kinase

Additional Terms

• hypomagnesemia with secondary hypocalcemia (HSH)

Internet Database

OMIM: 607009
OMIM: 602014
UniProt: [1]

References

UniProt [2]

transient receptor potential cation channel subfamily M member 6 (channel kinase 2, melastatin-related TRP cation channel 6, TRPM6, CHAK2)