Transient Receptor Potential Cation Channel Subfamily A Member 1

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Expression 5 Pathology 6 More General Terms 7 Internet Database 8 References

Function

• receptor-activated non-selective cation channel involved
• detection of sensations such as cold, pain or sounds perception
• cold nociception, activated by cold temperature below 17 degrees Celsius
• pain sensation triggered by mustard oil or capsaicin
• ionotropic cannabinoid receptor
• component for the mechanosensitive transduction channel of hair cells in inner ear ( putative)
• uses phosphatidylinositol second messenger system ( putative)
• inhibited by ruthenium red

Structure

• belongs to the transient receptor family
• contains 15 ANK repeats

Compartment

• membrane

Expression

• expressed at very low level

Pathology

• may be expressed at a higher level in liposarcoma cells

More General Terms

• cell surface receptor
• ion channel
• transmembrane 6 protein

Internet Database

OMIM: 604775
Prosite: [1]
Prosite: [2]
UniProt: [3]

References

1. UniProt [4]
2. Protein Spotlight; Note: The power behind pain - Issue 82 of may 2007 [5]

transient receptor potential cation channel subfamily A member 1 (ankyrin-like with transmembrane domains protein 1, transformation sensitive-protein p120, TRPA1, ANKTM1)