Torcetrapib
From Anvita Health Wiki
Contents |
Indications
Dosage
Adverse-effects
- (reported in clinical trials)
- dizziness
- headache
- asthenia
- pain
- dyspepsia
- reactivation of Herpes simplex
- shingles ( Herpes zoster)
- sweating
- amnesia
- abnormal thinking
- increases cardiovascular events & all-cause mortality [6]
Laboratory
- adverse effects on serum aldosterone & serum HCO3-
Mechanism-of-action
- inhibition of cholesteryl ester transfer protein
- increases HDL cholesterol by 16-91% (dose-dependent) [3]
- 61% for dose of 120 mg BID in combination with 20 mg of atorvastatin QD [1]
- despite increasing HDL, increases cardiovascular events & all-cause mortality [6]
- reduces LDL cholesterol 17% in in combination with atorvastatin
More General Terms
Internet Database
PubChem: 159325
References
- Brousseau ME, Schaefer EJ, Wolfe ML, Bloedon LT, Digenio AG, Clark RW, Mancuso JP, Rader DJ. Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol. N Engl J Med. 2004 Apr 8;350(15):1505-15. PMID: [1]
- Brewer HB Jr. Increasing HDL Cholesterol Levels. N Engl J Med. 2004 Apr 8;350(15):1491-4. No abstract available. PMID: [2]
- Clark RW, Sutfin TA, Ruggeri RB, Willauer AT, Sugarman ED, Magnus-Aryitey G, Cosgrove PG, Sand TM, Wester RT, Williams JA, Perlman ME, Bamberger MJ. Raising high-density lipoprotein in humans through inhibition of cholesteryl ester transfer protein: an initial multidose study of torcetrapib. Arterioscler Thromb Vasc Biol. 2004 Mar;24(3):490-7. Epub 2004 Jan 22. PMID: [3]
- Bays H, Stein EA. Pharmacotherapy for dyslipidaemia--current therapies and future agents. Expert Opin Pharmacother. 2003 Nov;4(11):1901-38. Review. PMID: [4]
- Prescriber's Letter 11(5):27 2004 Detail-Document#: [5] (subscription needed) [6]
- Barter PJ et al, Effects of torcetrapib in patients at high risk for coronary events. N Engl J Med 2007, 357:2109 PMID: [7]
