Topical Glucocorticoid

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Contents 1 More Specific Terms 2 Introduction 3 Classification 4 Adverse-effects 5 More General Terms 6 References

More Specific Terms

• alclometasone (Aclovate, Acloson, Delonal)
• amcinonide (Cyclocort)
• betamethasone (Celestone, Diprosone, Valisone, Diprolene, Soluspan)
• clobetasol (Temovate, Clobex, Galderma)
• clocortolone (Cloderm)
• cortisol; hydrocortisone (Cortef, Solu-Cortef, Alphaderm, Cetacort, Cortenema, Hytone, Nutracort, Westcort)
• desoximetasone (Topicort)
• dexamethasone (Decadron, Maxidex, AK-Dex, Ozurdex)
• diflorasone (Florone, Maxiflor)
• difluprednate (Durezol)
• fluocinolone (Synalar, Synemol, Fluonid, Derma-Smoothe/FS, Synandrone)
• fluocinonide (Lidex, Fluonex)
• flurandrenolide (Cordran)
• halcinonide (Halog)
• halobetasol (Ultravate)
• mometasone (Elocon, Asmanex, Nasonex)
• prednicarbate (Dermatop)
• triamcinolone (TAC, Aristocort, Arsitospan, Kenacort, Kenalog, Nasocort, Azmacort, Trivaris)
• tridesilon; prednacinolone (Desonide)

Introduction

• Agents applied to skin. Excludes nasal & inhaled glucocorticoids

Classification

• class 1 (most potent)*

• clobetasol propionate 0.05%
• betamethasone dipropionate ointment 0.05%
• halobetasol propionate 0.o5%

• class 2

• augmented betamethasone diproprionate cream 0.05% (in optimized vehicle)
• fluocinonide 0.05%
• desoximetasone 0.25%

• class 3 (high potency)

• betamethasone dipropionate cream 0.05%
• betamethasone valerate ointment 0.1%
• triamcinolone acetonide ointment 0.1%
• triamcinolone acetonide cream 0.5%
• fluticasone propionate ointment 0.05%

• class 4

• triamcinolone acetonide cream 0.1%
• hydrocortisone valerate ointment 0.2%
• fluocinolone acetonide ointment 0.025%
• fluticasone propionate cream 0.05%

• class 5

• betamethasone valerate cream 0.1%
• hydrocortisone valerate cream 0.2%
• triamcinolone acetonide lotion 0.1%
• fluocinolone acetonide cream 0.025%

• class 6

• betamethasone valerate lotion 0.05%
• desonide cream 0.05%
• fluocinolone acetonide cream 0.01%
• fluocinolone acetonide solution 0.05%

• class 7 (least potent)*

• hydrocortisone 0.5-1%
  

• * classifiacton from most to least potent

Adverse-effects

• thinning of skin is common
• hyperglycemia within chronic use of potent agents [2]
  
• drug adverse effects of glucocorticoids
• drug adverse effects of immunosuppressive agents

More General Terms

• topical anti-inflammatory agent
• glucocorticoid

References

1. Prescriber's Letter 16(12): 2009 Comparison of Topical Corticosteroids Detail-Document#: [1] (subscription needed) [2]
2. Medical Knowledge Self Assessment Program (MKSAP) 15, American College of Physicians, Philadelphia 2009
3. Prescriber's Letter 18(10): 2011 Hyperglycemia Associated with Non-oral and Locally Injected Corticosteroids Detail-Document#: [3] (subscription needed) [4]

topical glucocorticoid (topical steroid)