Tissue Transglutaminase Iga Autoantibody

From Anvita Health Wiki

Contents 1 Etiology 2 Clinical-significance 3 More General Terms 4 Additional Terms 5 References

Etiology

• celiac disease

Clinical-significance

• celiac disease is precipitated by ingestion of the protein gliadin, a component of wheat gluten
• gliadin initiates mucosal damage which involves an immunological process in individuals with a genetic predisposition
• IgA antibodies against gliadin & endomysium, a structure of smooth muscle connective tissue are found in patients with celiac disease
• tissue transglutaminase is the endomysial autoantigen
• gliadin is a preferred substrate for tissue transglutaminase

More General Terms

• serology
• autoantibody

Additional Terms

• tissue transglutaminase IgG in serum

References

1. Dieterich W, Ehnis T, Bauer M, Donner P, Volta U, Riecken EO, Schuppan D. Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med. 1997 Jul;3(7):797-801. PMID: [1]
2. Dieterich W, Laag E, Schopper H, Volta U, Ferguson A, Gillett H, Riecken EO, Schuppan D. Autoantibodies to tissue transglutaminase as predictors of celiac disease. Gastroenterology. 1998 Dec;115(6):1317-21 PMID: [2]
3. Sulkanen S, Halttunen T, Laurila K, Kolho KL, Korponay-Szabo IR, Sarnesto A, Savilahti E, Collin P, Maki M. Tissue transglutaminase autoantibody enzyme-linked immunosorbent assay in detecting celiac disease. Gastroenterology. 1998 Dec;115(6):1322-8. PMID: [3]
4. Blackwell PJ, Hill PG, Holmes GK. Autoantibodies to human tissue transglutaminase: superior predictors of coeliac disease. Scand J Gastroenterol. 2002 Nov;37(11):1282-5. PMID: [4]
5. Medical Knowledge Self Assessment Program (MKSAP) 15, American College of Physicians, Philadelphia 2009

tissue transglutaminase IgA autoantibody