Tiagabine

From Anvita Health Wiki

Contents 1 Indications 2 Dosage 3 Pharmacokinetics 4 Adverse-effects 5 Mechanism-of-action 6 More General Terms 7 Internet Database 8 References

Indications

• adjunctive treatment of partial seizures
• OFF LABEL use for migraine, bilar disorder

Dosage

• start 4 mg PO QD
• increase by increments of 4 mg
• wait one week prior to 1st dose increase; thereafter may increase dose daily
• maximum dose 32 mg
• higher doses should be given in divided doses BID- QID

• Tabs: 4, 12, 16, 20 mg

Pharmacokinetics

• protein binding 96%
• 1/2life 6.7 hours
• elimination: 25% in urine, 63% in feces

Adverse-effects

• all dose-related
• CNS: - dizziness, headache, somnolence, CNS depression, memory impairment, ataxia, seizures [2,3]
• abnormal vision, deteriorating color vision
• tremor
• nausea
  
• drug adverse effects of anticonvulsants

Mechanism-of-action

• may inhibit reuptake of GABA by presynaptic terminals

More General Terms

• anticonvulsant

Internet Database

PubChem: 60648
PubChem: 91274
PubChem: 5466

References

1. Geriatric Dosage Handbook, 6th edition, Selma et al eds, Lexi-Comp, Cleveland, 2001
2. FDA Medwatch [1]
3. Prescriber's Letter 12(4): 2005 FDA Public Health Advisory Seizures in Patients without Epilepsy Being Treated with Gabitril (tiagabine) Detail-Document#: [2] (subscription needed) [3]
4. Medical Knowledge Self Assessment Program (MKSAP) 15, American College of Physicians, Philadelphia 2009

tiagabine (Gabitril)