Thrombin

From Anvita Health Wiki

Contents 1 More Specific Terms 2 Function 3 More General Terms 4 Additional Terms

More Specific Terms

• thrombin topical (Recothrom)

Function

• vitamin K-dependent serine protease form by proteolysis of prothrombin
• functions in blood homeostasis, inflammation & wound healing
• proteolytically activates

• fibrinogen to fibrin
• factor V to factor Va
• factor VIII to factor VIIIa
• factor XIII to factor XIIIa
• in complex with thrombomodulin, protein C
• platelet factor IIa

• selective cleavage of Arg-|- Gly bonds in fibrinogen to form fibrin & release fibrinopeptides A & B

More General Terms

• serine protease trypsin family
• coagulation factor
• multisubunit protein

Additional Terms

• coagulation cascade
• proteinase-activated receptor 3; PAR-3; thrombin receptor-like 2; coagulation factor II receptor-like 2 (F2RL2, PAR3)
• prothrombin; coagulation factor II; contains: activation peptide fragment 1; activation peptide fragment 2; thrombin light chain; thrombin heavy chain (F2)
• thrombin receptor; proteinase-activated receptor 1; PAR-1; coagulation factor 2 receptor (F2R, CF2R, PAR1, TR)
• thrombin/thromboplastin (Thrombinar)

thrombin; coagulation factor IIa