Thioguanine

From Anvita Health Wiki

Contents 1 Indications 2 Contraindications 3 Dosage 4 Monitor 5 Adverse-effects 6 Drug-interactions 7 More General Terms 8 Additional Terms 9 Internet Database 10 References

Indications

• acute non-lymphocytic leukemia

• remission induction
• consolidation
• maintenance

• treatment of chronic myelogenous leukemia

Contraindications

• history of previous resistance to thioguanine or 6-mercapto- purine
  

• pregnancy category = d

Dosage

• drink plenty of liquids
• dosage reduction with renal or hepatic insufficiency

• Tabs: 40 mg.

Monitor

• uric acid
• complete blood count ( CBC)
• liver function tests ( serum ALT, serum AST, serum bilirubin, serum alkaline phosphatase) weekly initally, then monthly [3]

Adverse-effects

• common (> 10%)

• mild nausea/vomiting*, anorexia, stomatitis, diarrhea
• myelosuppression

• WBC & platelet: moderate
• onset 7-10 days
• nadir: 14 days
• recovery: 21 days

• less common (1-10%)

• hyperuricemia, unsteady gait, rash

• uncommon (< 1%)

• neurotoxicity, hepatitis, jaundice, veno-occlusive hepatic disease, photosensitivity

• * emetic potential low Toxicology: not dialyzable; treatment is supportive

Drug-interactions

• busulfan

More General Terms

• mercaptopurine; thiopurine
• antineoplastic agent (chemotherapeutic agent)

Additional Terms

• acute myeloid leukemia (AML)
• chronic myeloid leukemia (CML, granulocytic leukemia)

Internet Database

PubChem: 2723601
PubChem: 407008
PubChem: 1537

References

1. Kaiser Permanente Northern California Regional Drug Formulary, 1998
2. Department of Veterans Affairs, VA National Formulary
3. Prescriber's Letter 17(7): 2010 Recommended Lab Monitoring for Common Medications Liver Function Test Scheduling Detail-Document#: [1] (subscription needed) [2]

thioguanine