Thiazide Sensitive Sodium Chloride Cotransporter
From Anvita Health Wiki
Contents |
Function
- electrically silent transporter system
- mediates Na+ & chloride reabsorption
- principal mediator of Na+ & Cl- reabsorption in the distal convoluted tubule of the kidney
Structure
- belongs to the SLC12A transporter family
Compartment
- membrane
Expression
- predominant in kidney
Pathology
- defects in SLC12A3 are the cause of Gitelman syndrome
Pharmacology
- inhibited by thiazide diuretics used in treatment of hypertension
More General Terms
Internet Database
Kegg: [1]
OMIM: 263800
OMIM: 600968
UniProt: [2]
References
