Tfiie

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Genetics 4 More General Terms 5 References

Function

• initiates transcription in gene with RNA polymerase 2, TFIID (or Sp1?), & TFIIB bound
• recruits TFIIH to the initiation complex & stimulates the RNA polymerase 2 C-terminal domain kinase & DNA-dependent ATPase activities of TFIIH [2]
• both TFIIH & TFIIE are required for promoter clearance by RNA polymerase 2
• required for transcription

Structure

• tetramer of 2 TFIIE-alpha & 2 TFIIE-beta chains [2]

Genetics

• encoded by 2 genes

More General Terms

• adenosine triphosphatase (ATPase)
• molecular complex
• general transcription factor

References

1. Molecular Cell Biology (2nd ed) Darnell J; Lodish H & Baltimore D (eds), Scientific American Books, WH Freeman, NY 1990, pg 294
2. Buratowski S. The basics of basal transcription by RNA polymerase II. Cell. 1994 Apr 8;77(1):1-3. Review. No abstract available. PMID: [1]
3. Drapkin R, Reinberg D. The multifunctional TFIIH complex and transcriptional control. Trends Biochem Sci. 1994 Nov;19(11):504-8. Review. PMID: [2]
4. UniProt [3]

transcription factor IIE (TFIIE)