Tcr Gamma

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Contents 1 More Specific Terms 2 Function 3 More General Terms 4 Additional Terms 5 Internet Database 6 References

More Specific Terms

• T-cell receptor gamma chain C region PT-gamma-1/2
• T-cell receptor gamma chain V region PT-gamma-1/2 (TRGV3)

Function

• the T-cell receptor forms non covalent interactions with a series of transmembrane signalling subunits, delta, gamma, epsilon & zeta each of which contains 1-3 copies of the motif YXX[LI]X(6-8)YXX[LI]
• phosphorylation of these Tyr-containing sites in antigen- stimulated T-cells (presumably by lck) creates a binding site(s) for the SH2-domains of Zap-70.
• Zap-70, in turn stimulates PLC-gamma1, leading to the rise in intracellular Ca+2

More General Terms

• T cell receptor signalling subunit

Additional Terms

• lck proto-oncogene protein
• phospholipase C-gamma 1 (PLCG1, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1, PLC-2)
• Zap-70 tyrosine kinase; zeta-associated protein 70 kD; Syk-related tyrosine kinase (ZAP70, SRK)

Internet Database

UniProt: [1]
UniProt: [2]
OMIM: 186970

References

- Pawson T Protein modules and signalling networks Nature 373:573 1995 PMID: [3] T cell receptor gamma