Tcr Epsilon
From Anvita Health Wiki
Contents |
Function
- the T-cell receptor forms non covalent interactions with a series of transmembrane signalling subunits, delta, gamma, epsilon & zeta each of which contains 1-3 copies of the motif YXX[LI]X(6-8)YXX[LI]
- phosphorylation of these Tyr-containing sites in antigen- stimulated T-cells (presumably by lck) creates a binding site(s) for the SH2-domains of Zap-70.
- Zap-70, in turn stimulates PLC-gamma1, leading to the rise in intracellular Ca+2
More General Terms
Additional Terms
- lck proto-oncogene protein
- phospholipase C-gamma 1 (PLCG1, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1, PLC-2)
- Zap-70 tyrosine kinase; zeta-associated protein 70 kD; Syk-related tyrosine kinase (ZAP70, SRK)
References
- Pawson T Protein modules and signalling networks Nature 373:573 1995 PMID: [1]
