Tcp1 Ring Complex

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 More General Terms 5 References

Function

• molecular chaperone
• assists the folding of proteins upon ATP hydrolysis
• folding of actin & tubulin
• hetero- oligomeric complex of 850-900 kD that forms 2 stacked rings, 12-16 nm in diameter
• interacts with PACRG

Structure

• subunits: CCT1 CCT2, CCT3, CCT4, CCT5, CCT6, CCT7, CCT8, HSP70, chaperonin-10

Compartment

• cytoplasm

More General Terms

• macromolecular complex
• adenosine triphosphatase (ATPase)

References

1. Yaffe MB, Farr GW, Miklos D, Horwich AL, Sternlicht ML, Sternlicht H. TCP1 complex is a molecular chaperone in tubulin biogenesis. Nature. 1992 Jul 16;358(6383):245-8. PMID: [1]
2. Lewis VA, Hynes GM, Zheng D, Saibil H, Willison K. T-complex polypeptide-1 is a subunit of a heteromeric particle in the eukaryotic cytosol. Nature. 1992 Jul 16;358(6383):249-52. PMID: [2]
3. UniProt [3]

TCP1 ring complex (T-complex protein 1, chaperonin containing T-complex polypeptide 1)