T Plastin

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Expression 5 More General Terms 6 Internet Database 7 References

Function

• actin-bundling protein found in intestinal microvilli, hair cell stereocilia, & fibroblast filopodia
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• monomer
• contains 2 actin-binding domains
• contains 4 CH (calponin-homology) domains
• contains 2 EF-hand domains

Compartment

• cytoplasm

Expression

• expressed in a variety of organs, including muscle, brain, uterus & esophagus

More General Terms

• plastin or fimbrin

Internet Database

UniProt: [1]
Entrez gene: 5358
OMIM: 300131
Prosite: [2]
Prosite: [3]
Prosite: [4]
Prosite: [5]
Prosite: [6]

References

UniProt [7]

plastin-3; T-plastin (PLS3)