Syntrophin Alpha

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Expression 5 More General Terms 6 Internet Database 7 References

Function

• adapter protein that binds to & probably organizes the subcellular localization of a variety of membrane proteins
• may link various receptors to the actin cytoskeleton & the extracellular matrix via the dystrophin glycoprotein complex
• plays a role in synapse formation & in organization of UTRN & acetylcholine receptors at the neuromuscular synapse
• binds to phosphatidylinositol 4,5-biphosphate ( putative)
• phosphorylated by CaM-kinase 2; phosphorylation may inhibit interaction with DMD ( putative)
• interacts with the other members of the syntrophin family SNTB1 & SNTB2; SGCG & SGCA of dystrophin glycoprotein complex; NOS1; GRB2; the Na+ channel proteins SCN4A & SCN5A; F-actin & calmodulin ( putative)
• interacts with dystrophin protein DMD & related proteins DTNA & UTRN & with MAPK12, TGFA & GA

Structure

• monomer & homodimer
• the 1st PH domain mediates oligomerization (Ca+2-dependent), & association with phosphatidylinositol 4,5-biphosphate ( putative)
• the PDZ domain binds to the last 3 or 4 amino acids of ion channels & receptor proteins; association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane
• the SU domain binds calmodulin (Ca+2-dependent)
• belongs to the syntrophin family
• contains 1 PDZ domain ( DHR domain)
• contains 2 PH domains
• contains 1 SU domain ( syntrophin unique)

Compartment

• cell membrane, sarcolemma
• peripheral membrane protein; cytoplasmic side ( putative)
• cell junction ( putative)
• cytoplasm, cytoskeleton
• in skeletal muscle, localizes at the cytoplasmic side of the sarcolemmal membrane & at neuromuscular junctions

Expression

• high expression in skeletal muscle & heart
• low expression in brain, pancreas, liver, kidney & lung
• not detected in placenta

More General Terms

• syntrophin (dystrophin-associated protein)
• phosphoprotein

Internet Database

Entrez gene: 6640
Kegg: [1]
OMIM: 601017
Prosite: [2]
Prosite: [3]
UniProt: [4]

References

1. UniProt [5]
2. OMIM [6]
3. Entrez Gene [7]

alpha-1-syntrophin; 59 kD dystrophin-associated protein A1 acidic component 1; Pro-TGF-alpha cytoplasmic domain-interacting protein 1; TACIP1; syntrophin-1 (SNTA1 SNT1)