Synaptophysin

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Expression 5 More General Terms 6 Internet Database 7 References

Function

• possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane
• ubiquitinated; mediated by SIAH1 or SIAH2 & leading to its subsequent proteasomal degradation ( putative)

Structure

• homohexamer or homotetramer
• the Ca+2-binding activity is thought to be localized in the cytoplasmic tail of the protein
• belongs to the synaptophysin/ synaptobrevin family
• contains 1 MARVEL domain

Compartment

• cytoplasmic vesicle, secretory vesicle
• synaptic vesicle membrane
• cell junction, synapse, synaptosome
• may colocalize with the amyloid precursor protein ( APP)

Expression

• characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal & epithelial phenotype

More General Terms

• transmembrane 4 protein
• ion channel
• oligomerizing protein
• glycoprotein

Internet Database

Prosite: [1]
UniProt: [2]
OMIM: 313475
Kegg: [3]
Entrez gene: 6855

References

1. Mandell JW et al Synapsins in the vertebrate retina: absence from ribbon synapses and heterogeneous distribution among conventional synapses. Neuron 1990 Jul;5(1):19-33 PMID: [4]
2. Molecular Cell Biology (2nd ed) Darnell J; Lodish H & Baltimore D (eds), Scientific American Books, WH Freeman, NY 1990, pg 791
3. Entrez Gene [5]
4. UniProt [6]
5. Wikipedia; Note: synaptophysin entry [7]

synaptophysin; major synaptic vesicle protein p38 (SYP)