Streptozocin

From Anvita Health Wiki

Contents 1 Introduction 2 Indications 3 Contraindications 4 Dosage 5 Adverse-effects 6 Drug-interactions 7 Test-interactions 8 More General Terms 9 Internet Database 10 References

Introduction

• Tradename: Zanosar.

Indications

• treatment of metastatic islet cell carcinoma of the pancreas
• carcinoid tumor & carcinoid syndrome
• Hodgkin's disease
• palliative treatment of colorectal carcinoma

Contraindications

• Caution:
• avoid aspirin
• use electric razor
  

• pregnancy category = x
• safety in lactation = -

Dosage

• may be injected by rapid IV push
• dosage adjustment for renal failure
• refrigerate & protect from light
• discard refrigerated reconstituted solutions after 12 hours

• Powder for injection: 1 g

Adverse-effects

• common (> 10%)

• nephrotoxicity (25-75%), nausea/vomiting

• less common (1-10%)

• diarrhea, hypoglycemia, pain at site of injection

• uncommon (< 1%)

• liver dysfunction, leukopenia, thrombocytopenia, hematologic toxicity

• other

• may cause permanent sterility
• may cause birth defects
  
• drug adverse effects of alkylating agents

Drug-interactions

• phenytoin
• other potentially nephrotoxic drugs

Test-interactions

• increases serum K+

More General Terms

• alkylating agent
• antineoplastic agent (chemotherapeutic agent)

Internet Database

PubChem: 29327
PubChem: 5299

References

1. Kaiser Permanente Northern California Regional Drug Formulary, 1998
2. Department of Veterans Affairs, VA National Formulary

streptozocin (Zanosar)