Sphingomyelin Synthase 2
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Contents |
Function
- bidirectional lipid cholinephosphotransferase
- capable of converting phosphatidylcholine & ceramide to sphingomyelin & diacylglycerol & vice versa
- direction is dependent on the relative concentrations of diacylglycerol & ceramide as phosphocholine acceptors
- directly & specifically recognizes the choline head group on the substrate
- also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate
- does not function strictly as a sphingomyelin synthase
- required for cell growth
- palmitoylated on Cys-331, Cys-332, Cys-343 & Cys-348
- palmitoylated plays a role in plasma membrane localization
- palmitoylated plays a role in plasma membrane localization
- ceramide + phosphatidylcholine = sphingomyelin + 1,2-diacyl-sn-glycerol
- Inhibition:
- inhibited by bacterial PC- phospholipase C inhibitor D609
Structure
- belongs to the sphingomyelin synthase family
Compartment
- plasma membrane, Golgi membrane
- predominantly plasma membrane, some in Golgi
- multi-pass membrane protein
Expression
Notes
- overexpression of the human protein in mouse causes increased non-HDL- sphingomyelin & non-HDL cholesterol levels, decreased HDL- sphingomyelin & HDL-cholesterol levels & increases lipoprotein atherogenic potential
More General Terms
Internet Database
Entrez gene: 166929
Kegg: [1]
OMIM: 611574
UniProt: [2]
References
UniProt [3]
