Sorafenib

From Anvita Health Wiki

Contents 1 Introduction 2 Indications 3 Adverse-effects 4 Mechanism-of-action 5 More General Terms 6 Internet Database 7 References

Introduction

• Trademark: Nexavar, FDA approved 2005

Indications

• advanced kidney cancer ( renal cell carcinoma)

Adverse-effects

• fatigue

Mechanism-of-action

• inhibits multiple protein kinases

• Manufacturer: Bayer/Onyx

More General Terms

• antineoplastic agent (chemotherapeutic agent)
• protease inhibitor

Internet Database

PubChem: 216239

References

1. Prescriber's Letter 13(2): 2006 Detail-Document#: [1] (subscription needed) [2]
2. National Guideline Clearinghouse
   - Sorafenib for the treatment of advanced hepatocellular carcinoma. National Institute for Health and Clinical Excellence (NICE) ngc-guideline: [3]

sorafenib (Nexavar)