Solute Carrier Family 6
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More Specific Terms
- betaine transporter
- choline transporter
- solute carrier family 6 member 3 (SLC6A3, dopamine transporter)
- glutamate/aspartate transporter (excitatory amino acid transporter)
- solute carrier family 6 member 1 (SLC6A1, gamma amino butyric acid [GABA] transporter-1)
- solute carrier family 6 member 6 (SLC6A6, taurine transporter)
- Na+ & Cl- dependent creatine transporter 1 (creatine transporter 1, CT1, solute carrier family 6 member 8, SLC6A8)
- solute carrier family 6 member 10 (SLC6A10, Na+ & Cl- dependent creatine transporter 2
- Na+ & Cl- dependent transporter XTRP2 (solute carrier family 6 member 18, SLC6A18, XTRP2)
- Na+ & Cl- dependent transporter XTRP3 (solute carrier family 6 member 20, neurotransmitter transporter rB21A homolog, SLC6A20, XT3, XTRP3)
- Na+ dependent noradrenaline transporter; norepinephrine transporter; NET; solute carrier family 6 member 2 (SLC6A2, NAT1, NET1, SLC6A5)
- solute carrier family 6 member 4 (SLC6A4, serotonin [5HT] transporter)
- solute carrier family 6 member 13 (SLC6A13, Na+/Cl- dependent GABA transporter 2
- solute carrier family 6 member 11 (SLC6A11, Na+/Cl- dependent GABA transporter 3, GABT3, GAT3
- solute carrier family 6 member 9 (SLC6A9, Na+/Cl- dependent glycine transporter 1, GlyT1
- solute carrier family 6 member 10 (SLC6A19, Na+ dependent neutral amino acid transporter B0, system B0 neutral amino acid transporter, B0AT1)
- solute carrier family 6 member 12; Na+/Cl- betaine/GABA transporter; BGT-1 (SLC6A12)
- solute carrier family 6 member 14 (SLC6A14, Na+ & Cl- dependent neutral & basic amino acid transporter B0+, amino acid transporter ATB0+)
- solute carrier family 6 member 15 (SLC6A15, orphan Na+ & Cl- dependent neurotransmitter transporter NTT73)
- solute carrier family 6 member 16 (SLC6A16, orphan Na+ & Cl- dependent neurotransmitter transporter NTT5)
- solute carrier family 6 member 17 (SLC6A17, orphan Na+ & Cl- dependent neurotransmitter transporter NTT5)
- solute carrier family 6 member 5; Na+- & chloride-dependent glycine transporter 2; GlyT-2; GlyT2 (SLC6A5, GLYT2, NET1)
- solute carrier family 6 member 7; Na+-dependent proline transporter (SLC6A7, PROT)
Introduction
- Largest of the human solute carrier protein families. Comprises at least 20 members. Originally referred to as neurotransmitter transporter family because it first members encode transporters for the neurotransmitters GABA, noradrenaline, serotonin & dopamine. Orphan members of the family appear to encode transporters for amino acids. [2] SLC6 transporters are ion-coupled ( symporters).
More General Terms
Internet Database
Prosite: [1]
References
- Uhl TINS 1992 15:265-8
- Broer S The SLC6 orphans are forming a family of amino acid transporters. Neurochem Int 2006 48:559 PMID: [2]
- Hahn MK & Blakely RD The functional impact of SLC6 transporter genetic variation. Annu Rev Pharmacol Toxicol 2007, 47:401 PMID: [3]
