Sodium Citrate/citric Acid

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Contents 1 More Specific Terms 2 Introduction 3 Indications 4 Dosage 5 Monitor 6 Adverse-effects 7 Drug-interactions 8 Mechanism-of-action 9 More General Terms 10 Internet Database 11 References

More Specific Terms

• sodium citrate/citric acid (Bicitra)

Introduction

• Tradename: Bicitra (also available as citric acid alkaline syrup)

Indications

• treatment of metabolic acidosis, especially caused by renal tubular acidosis
• long-term maintenance of alkaline urine

• gouty nephropathy

Dosage

• dilute in water
• adults 15-30 mL with water after meals & QHS
• children: 2-3 meq/kg//day divided TID- QID or 5-15 mL after meals & QHS
  

• Solution: (oral)

• sodium citrate 500 mg & citric acid 334 mg/5 mL (473 mL)

Monitor

• urinary pH

Adverse-effects

• not common (1-10%)

• metabolic alkalosis, tetany, cardiac arrhythmias due to hypocalcemia, hyperkalemia, hypernatremia, diarrhea, nausea/vomiting

• other

• calcium citrate urolithiasis
• exacerbation of CHF

• edema
• calcium citrate may increase gastrointestinal Al+3 absorption

Drug-interactions

• increased excretion of chlorpropamide, lithium, methotrexate, salicylates, tetracyclines
• decreased excretion of anorexiants, quinidine, sympathomimetics

Mechanism-of-action

• systemic & urinary alkalinizer

More General Terms

• pharmacologic combination
• salt
• metabolic agent (metabolic modifier)

Internet Database

PubChem: 107687

References

1. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998 Department of Veterans Affairs, VA National Formulary
2. Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
3. Kaiser Permanente Northern California Regional Drug Formulary, 1998

sodium citrate/citric acid (Bicitra)