Sodium Channel Protein 11 Alpha
From Anvita Health Wiki
Contents |
Function
- mediates voltage-dependent Na+ permeability of excitable membranes
- assumes opened or closed conformation in response to voltage difference across the membrane
- forms a Na+-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient
- tetrodotoxin-resistant Na+ channel isoform
- role in association with receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization
- voltage-resistant Na+ channel consists of an ion conducting pore forming alpha-subunit regulated by one or more auxiliary subunits SCN1B, SCN2B & SCN3B
Structure
- contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) & one positively charged segment (S4)
- segment S4 is probably the voltage- sensor & is characterized by a series of positively charged amino acids at every third position
- belongs to the Na+ channel family
Compartment
- membrane
Alternative-splicing
- named isoforms=3
Expression
- expressed in the dorsal root ganglia, trigeminal ganglia, olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine & placenta
More General Terms
- transmembrane 24 protein
- voltage-dependent Na+ channel protein alpha subunit
- phosphoprotein
- glycoprotein
Additional Terms
Internet Database
Entrez gene: 11280
Kegg: [1]
OMIM: 604385
UniProt: [2]
References
