Sjogren Syndrome Type A Antigen

From Anvita Health Wiki

Contents 1 More Specific Terms 2 Function 3 More General Terms 4 Additional Terms 5 References

More Specific Terms

• 52 kD Ro protein; Sjoegren syndrome type A antigen; SS-A; Ro(SS-A); 52 kD ribonucleoprotein autoantigen Ro/SS-A; tripartite motif-containing protein 21; RING finger protein 81 (TRIM21, RNF81, Ro52, SSA1)
• 60 kD SS-A/Ro ribonucleoprotein; 60 kD ribonucleoprotein Ro; RoRNP; 60 kD Ro protein; Ro 60 kD autoantigen; TROVE domain family member 2; Sjoegren syndrome type A antigen; SS-A; Sjoegren syndrome antigen A2 (TROVE2, Ro60, SSA2)

Function

• together with Y-RNA, component of Ro ribonucleoprotein particles
• in the free state, Ro binds to a variety of misfolded RNAs including misfolded 5S rRNAs, & is thought to act as some sort of quality control mechanism
• Y RNA appears to function as a repressor of Ro

More General Terms

• biochemistry

Additional Terms

• anti-SSA/Ro in serum
• Sjogren's syndrome (keratoconjunctivitis sicca, autoimmune epitheliitis)

References

1. UniProt [1]
2. Wikipedia: Y RNA [2]

Sjogren syndrome type A antigen (SSA/Ro)