Silver Sulfadiazine

From Anvita Health Wiki

Contents 1 Introduction 2 Indications 3 Contraindications 4 Dosage 5 Pharmacokinetics 6 Adverse-effects 7 Drug-interactions 8 More General Terms 9 Internet Database 10 References

Introduction

• Tradename: Silvadene.

Indications

• prevention & treatment of infections in 2nd & 3rd degree burns
• wound dressing for pressure ulcers [4]

• malodorous wounds
• wounds with exudates
• suspected high bacterial load
• periwound inflammation
• slow healing wounds

Contraindications

• children < 2 months of age (sulfa drugs compete with bilirubin for protein- binding sites)

• Caution:

• G6PD deficiency
• renal impairment

• pregnancy-category :value B)
• safety-in-lactation :value -

Dosage

• burns: 1% cream applied to thickness of 1/16 inch QD/ BID
• local anesthetic may be needed prior to application Cream (topical): 10 mg/g (1%) 20, 50, 85, 400, 1000 g.

• Also contains methylparaben & propylene glycol.

Pharmacokinetics

• up to 1% of silver is absorbed
• up to 10% of the sulfa component may be absorbed

Adverse-effects

• common (> 10%)

• burning

• less common (1-10%)

• itching, rash, erythema multiforme, skin discoloration, hemolytic anemia, leukopenia, agranulocytosis, aplastic anemia, hepatitis, pain, interstitial nephritis, allergic reactions*

• uncommon (< 1%)

• photosensitivity

• * allergic reactions may be related to sulfa component

Drug-interactions

• silver may inactivate topical proteolytic enzymes
  
• drug interaction(s) of antibiotics with warfarin

More General Terms

• other antibiotic
• dermatologic agent

Internet Database

PubChem: 441244
PubChem: 452254
PubChem: 438204
PubChem: 31011
PubChem: 5214

References

1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996.
2. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
3. Kaiser Permanente Northern California Regional Drug Formulary, 1998
4. Geriatric Review Syllabus, 7th edition Parada JT et al (eds) American Geriatrics Society, 2010

silver sulfadiazine (Silvadene)