Sigma 1 Type Opioid Receptor
From Anvita Health Wiki
Contents |
Function
- lipid transport from endoplasmic reticulum
- involved in a wide array of cellular functions via regulating biogenesis of lipid microdomains at the plasma membrane
- regulation of different receptors
- regulates ion channels, i.e. K+ channel
- may modulate neurotransmitter release
- Ca+2 signaling
- in conjunction with ANK2 modulates ITP3R-dependent Ca+ efflux at the endoplasmic reticulum
- cell proliferation, survival & cell death
- originally identified for its ability to bind various psychoactive drugs
- involved in learning processes, memory & mood alteration
- depletion of OPRS1 by RNAi inhibits growth & survival signaling cascades & induces cell death; the OSPR1 antagonist rimcazole produces the same effect
Structure
- belongs to the ERG2 family
Compartment
- nucleus, nuclear inner membrane, nuclear outer membrane
- endoplasmic reticulum, endoplasmic reticulum membrane
- lipid droplet, cell junction, cell membrane
- targeted to lipid droplets, cholesterol & galactosylceramide- enriched domains of the endoplasmic reticulum
- enriched at cell-cell communication regions, growth cone & postsynaptic structures
- localization modulated by ligand-binding
Alternative-splicing
- named isoforms=5
Expression
- widely expressed
- especially in liver, colon, prostate, placenta, small intestine, heart, pancreas
- expressed in the retina by retinal pigment epithelial cells
More General Terms
Internet Database
Entrez gene: 10280
Kegg: [1]
OMIM: 601978
UniProt: [2]
References
