Sialyltransferase 2

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Alternative-splicing 5 Expression 6 More General Terms 7 Internet Database 8 References

Function

• transfers sialic acid from the donor of substrate CMP- sialic acid to galactose containing acceptor substrates
• alpha-2,6- sialyltransferase activity toward oligosaccharides that have the gal-beta-1,4- GlcNAc sequence at the non- reducing end of their carbohydrate groups
• weak or no activities toward glycoproteins & glycolipids
  

• CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N- acetyl-beta-D- glucosamine <--> CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4- N- acetyl-beta-D- glucosamine
  
• Kinetic parameters:

• KM=0.74 mM for gal-beta-1,4- GlcNAc-beta-O-octyl
• KM=0.71 mM for gal-beta-1,4- GlcNAc
• KM=0.48 mM for lacto-N-neotetraose

Structure

• belongs to the glycosyltransferase 29 family

Compartment

• Golgi membrane

Alternative-splicing

• named isoforms=2

Expression

• weakly expressed in some tissues, including small intestine, colon & fetal brain
• induced by IL6 & IL8

More General Terms

• sialyltransferase
• glycoprotein
• membrane protein

Internet Database

OMIM: 608472
UniProt: [1]

References

UniProt [2]

beta-galactoside alpha-2,6-sialyltransferase 2; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2; alpha 2,6-ST 2; monosialoganglioside sialyltransferase; ST6gal II; ST6gal-II; ST6galII; hST6gal II (ST6GAL2, KIAA1877, SIAT2)