Siah2 Protein

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Expression 5 More General Terms 6 Internet Database 7 References

Function

• E3 ubiquitin ligase
• mediates ubiquitination & subsequent proteasomal degradation of target proteins.
• triggers the ubiquitin-mediated degradation of

• proteins involved in transcription regulation

• POU2AF1, PML, NCOR1

• cell surface receptor(s)

• DCC

• antiapoptotic protein(s)

• BAG1

• protein(s) involved in synaptic vesicle function in neurons

• SYP

• role in:

• apoptosis
• tumor suppression
• cell cycle
• transcription
• signaling processes

• has some overlapping function with SIAH1
• triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 can not

Structure

• the RING-type zinc finger domain is essential for ubiquitin ligase activity

Compartment

• cytoplasmic; predominantly, nuclear partially

Expression

• widely expressed at low level

More General Terms

• zinc finger protein
• E3 ubiquitin ligase

Internet Database

Entrez gene: 6478
Kegg: [1]
OMIM: 602213
Prosite: [2]
Prosite: [3]
Prosite: [4]
UniProt: [5]

References

UniProt [6]

E3 ubiquitin-protein ligase SIAH2; seven in absentia homolog 2; siah-2; hsiah2 (SIAH2)