Sevelamer

From Anvita Health Wiki

Contents 1 Introduction 2 Indications 3 Contraindications 4 Dosage 5 Pharmacokinetics 6 Adverse-effects 7 Mechanism-of-action 8 More General Terms 9 Internet Database 10 References

Introduction

• calcium & aluminum-free phosphate-binder

Indications

• reduction of serum phosphorus in patient with end-stage renal disease

Contraindications

• safety in lactation: +

Dosage

• 2-4 tablets with meals
• adjust does for target serum phosphorus of < 6 mg/dL

• Tabs: 403 mg.
• Renagel is hydrochloride, Renvela is carbonate salt

Pharmacokinetics

• not absorbed following oral administration

Adverse-effects

• dyspepsia
• nausea/vomiting

Mechanism-of-action

• calcium & aluminum-free phosphate-binder within intestines
• cross-linked poly( allylamine hydrochloride)
• reduces cholesterol & LDL cholesterol

More General Terms

• metabolic agent (metabolic modifier)

Internet Database

PubChem: 159247

References

1. Micromedex vol 102
2. Prescriber's Letter 14(12): 2007 New Drug: Renvela (Sevelamer Carbonate) Detail-Document#: [1] (subscription needed) [2]

sevelamer (Renagel, Genzyme, Renvela)