Serotonin 3a Receptor

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Alternative-splicing 5 Expression 6 More General Terms 7 Internet Database 8 References

Function

• one of the several receptors for 5-hydroxytryptamine ( serotonin)
• ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons
• cation-specific, but otherwise relatively nonselective, ion channel
• forms pentahomomeric complex as well as pentaheteromeric complex with HTR3B or HTR3C or HTR3D or HTR3E
• homomeric complexes are functional but exhibit low conductance, decreased agonist & antagonist affinity with modified voltage dependence
• interacts with RIC3

Structure

• belongs to the ligand-gated ionic channel (TC 1.A.9) family
• the HA-stretch region of HTR3A seems to be responsible for the low conductance of HTR3A homomers compared to that of HTR3A/ HTR3B heteromers

Compartment

• cell junction, synapse, postsynaptic cell membrane

Alternative-splicing

• named isoforms=2

Expression

• expressed in cerebral cortex, amygdala, hippocampus, & testis
• detected in monocytes of the spleen & tonsil, in small & large intestine, uterus, prostate, ovary & placenta

More General Terms

• transmembrane 4e protein
• serotonin [5HT]-3 receptor
• glycoprotein

Internet Database

Kegg: [1]
OMIM: 182139
Prosite: [2]
UniProt: [3]
Entrez gene: 3359

References

UniProt [4]

serotonin [5HT]-3A receptor; 5-hydroxytryptamine receptor 3A; 5-HT3R; 5-HT3A; 5-HT-3; serotonin receptor 3A; serotonin-gated ion channel receptor (HTR3A, 5HT3R, HTR3)