Serine Threonine Protein Kinase Wnk3
From Anvita Health Wiki
Contents |
Function
- serine/threonine protein kinase
- role in regulation of electrolyte homeostasis, cell signaling, cell survival & cell proliferation
- activator of Na+-coupled chloride cotransporters
- inhibitor of K+-coupled chloride cotransporters
- phosphorylates WNK4
- regulates the phosphorylation of SLC12A1 & SLC12A2
- increases Ca+2 influx mediated by TRPV5 & TRPV6 by enhancing their membrane presence via a kinase-dependent pathway
- inhibits activity of KCNJ1 by decreasing its expression at the plasma membrane (non- catalytic)
- isoform 1
- isoforms 2, 3 & 4
Structure
- belongs to the protein kinase superfamily, Ser/Thr protein kinase family, WNK subfamily
- contains 1 protein kinase domain
Compartment
Alternative-splicing
- named isoforms=4
Expression
- isoform 1 is brain-specific
Notes
More General Terms
Internet Database
Entrez gene: 65267
Kegg: [1]
OMIM: 300358
Prosite: [2]
Prosite: [3]
Prosite: [4]
UniProt: [5]
References
UniProt [6]
