Serine Threonine Protein Kinase 36

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Alternative-splicing 4 Expression 5 More General Terms 6 Additional Terms 7 Internet Database 8 References

Function

• postnatal development
• homeostasis of cerebral spinal fluid
• ciliary function
• controls the activity of GLI1, GLI2, GLI3
• opposes effect of SUFU
• involved in hedgehog signaling
• binds gli protein
• interacts with SPAG16 & KIF27 ( putative)

• Cofactor: Mg+2

Structure

• belongs to the protein kinase superfamily, Ser/Thr protein kinase family
• contains 1 protein kinase domain

Alternative-splicing

• named isoforms=2

Expression

• expressed in adult testis
• expressed at low levels in most fetal tissues, adult ovaries

More General Terms

• serine/threonine kinase

Additional Terms

• suppressor of fused homolog; SUFUH (SUFU)

Internet Database

OMIM: 607652
Entrez gene: 27148
Prosite: [1]
Prosite: [2]
Prosite: [3]
UniProt: [4]

References

UniProt [5]

serine/threonine protein kinase 36; fused Drosophila homolog of FU; fused homolog (STK36 KIAA1278)