Serglycin
From Anvita Health Wiki
Contents |
Function
- proteoglycan core protein of heparin [3]
- role in formation of mast cell secretory granules & mediates storage of various compounds in secretory vesicles
- required for storage of some proteases in both connective tissue & mucosal mast cells & for storage of granzyme B in T lymphocytes
- role in localizing neutrophil elastase in azurophil granules of neutrophils
- mediates processing of MMP2
- role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis
- regulates the secretion of TNF-alpha & may also regulate protease secretion
- inhibits bone mineralization
- binds to activated CD44 & to GZMB
Structure
- O-glcosylated
- contains chondroitin sulfate & heparan sulfate ( putative)
- belongs to the serglycin family
Compartment
- cytoplasmic granule ( putative)
- secreted, extracellular space
- Golgi
- found in mast cell granules & in cytoplasmic granules of cytolytic T lymphocytes from where it is secreted upon cell activation
- located to Golgi apparatus during neutrophil differentiation
Expression
- secreted from activated cytolytic T lymphocytes
- secreted constitutively by endothelial cells & macrophages
- induced by EBV
More General Terms
Internet Database
UniProt: [1]
Entrez gene: 5552
Kegg: [2]
OMIM: 177040
References
- UniProt [3]
- Ruoslahti E, Yamaguchi Y. Proteoglycans as modulators of growth factor activities. Cell. 1991 Mar 8;64(5):867-9. Review. PMID: [4]
- Salmivirta M, Lidholt K, Lindahl U. Heparan sulfate: a piece of information. FASEB J. 1996 Sep;10(11):1270-9. Review. PMID: [5]
