Selenophosphate Synthetase 1

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 More General Terms 4 Internet Database 5 References

Function

• synthesizes selenophosphate from selenide & ATP
• activated by phosphate & by K+
  

• ATP + selenide + H2O = AMP + selenophosphate + phosphate

Structure

• homodimer
• belongs to the selenophosphate synthase 1 family class II subfamily
• the conserved active site Cys (or selenocysteine) residue in position 29 is replaced by a Thr; however, as function in selenoprotein synthesis is proven, it is possible Cys-31 is the active site

More General Terms

• kinase or ATP-phosphotransferase

Internet Database

Entrez gene: 22929
Kegg: [1]
OMIM: 600902
UniProt: [2]

References

UniProt [3]

selenide, water dikinase 1; selenium donor protein 1; selenophosphate synthase 1 (SEPHS1, SELD SPS, SPS1)