Saturated Solution Of Potassium Iodide

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Contents 1 Indications 2 Contraindications 3 Dosage 4 Adverse-effects 5 Drug-interactions 6 Mechanism-of-action 7 More General Terms 8 Additional Terms 9 References

Indications

• has been used as expectorant, but safer agents are available
• use preoperatively to reduce thyroid vascularity
• treatment of thyrotoxic crisis
• treatment of cutaneous sporotrichosis

Contraindications

• pregnancy

• Pregnancy category: D

Dosage

• expectorant:

• 300-650 mg after meals 3- 4 times/day
• optimal dose is 1-1.5 g TID

• thyroidectomy:

• 50-250 mg TID for 10-14 days prior to surgery

• thyrotoxic crisis:

• 50-250 mg TID
• does up to 500 mg every 4 hours have been used

• cutaneous sporotrichosis:

• 65-325 mg TID
• may increase by 150-250 mg/day
• max 4.5-9 g/day (or toxicity)

• 50 mg/drop.

Adverse-effects

• not common (> 10%)

• angioedema, fever, headache, urticaria, acne, goiter with hypothyroidism, metallic taste, GI upset, cutaneous & mucosal hemorrhage, eosinophilia, arthralgia, lymph node enlargement, soreness of teeth & gums, rhinitis

• other

• thyroid adenoma
• hypersensitivity reactions
• confusion
• nausea
• prolonged use may lead to hypothyroidism

Drug-interactions

• lithium, anti- thyroid medications: potentiation of anti- thyroid effect
• potassium-sparing diuretics, ACE inhibitors: may induce hyperkalemia
  
• drug interaction(s) of lithium carbonate with iodide salts

Mechanism-of-action

• iodine enhances secretion of respiratory fluids
• decreases mucus viscosity
• inhibition of release & synthesis of thyroid hormone

More General Terms

• potassium iodide (KI, Thyro-Block, Irostat)
• thyroid agent
• pharmacologic combination

Additional Terms

• sporotrichosis
• thyrotoxicosis

References

1. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
2. Kaiser Permanente Northern California Regional Drug Formulary, 1998

saturated solution of potassium iodide (SSKI)